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Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 271-276 doi: 10.1007/s11684-009-0054-1

Abstract: The aim of this paper is to investigate the relationship between hepatitis B virus (HBV) DNA levels during the course and the progression to cirrhosis with chronic hepatitis B. A total of 239 chronic hepatitis B patients confirmed by liver biopsy between 2001 and 2007 were followed up for a median of 28 months. Compared with the patients without cirrhosis, the patients progressed to cirrhosis were older and with higher HBV-DNA levels at end point. However, there was no significant difference in cirrhosis progression between different HBV-DNA groups at baseline ( = 0.531). Kaplan-Meier analysis showed higher HBV-DNA level at endpoint had increasing risk of cirrhosis ( = 0.019). The results of Cox model indicated that HBV-DNA levels at endpoint, stage of fibrosis, negative hepatitis B e antigen, and γ-glutamyl transpeptidase at baseline were independent risk factors of cirrhosis. The relative risk ratios were 1.898, 1.918, 8.976, and 1.006, respectively. Progression to cirrhosis in chronic hepatitis B patients is correlated with HBV-DNA levels during follow-up.

Keywords： hepatitis B     chronic     viral load     liver cirrhosis    

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A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections

Frontiers of Medicine doi: 10.1007/s11684-023-1011-0

Abstract: Paxlovid therapy tended toward early viral clearance and low viral load on Day 8.

Keywords： Paxlovid     hemodialysis     SARS-CoV-2     viral load     chest CT scan    

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Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 333-346 doi: 10.1007/s11684-020-0776-7

Abstract: Upon viral invasion, the innate immune system responds rapidly and plays a key role in activating theIn this review, the current understanding of innate immunity contributing to the restriction of RNA viralBesides the main role of immune cells in combating viral infection, the intercellular transfer of pathogenThis knowledge provides an enhanced understanding of the innate immune response to RNA viral infectionsin general and aids in the preparation for the existing and next emerging viral infections.

Keywords： innate immune     viral infection     intercellular signaling     metabolic changes     epigenetic changes    

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Analysis of antibiotic usage for viral community-acquired pneumonia in adults

Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 139-143 doi: 10.1007/s11684-019-0736-2

Abstract: The rationale for the antibiotic treatment of viral community-acquired pneumonia (CAP) in adults wasClinical data from 166 patients diagnosed with viral pneumonia across 14 hospitals in Beijing from NovemberA total of 163 (98.3%) patients with viral pneumonia were treated with antibiotics.A total of 39 of the 163 (23.9%) patients did not meet the guidelines for drug selection for viral CAPThe unreasonable use of antibacterial drugs for the treatment of viral CAP in adults is a serious concern

Keywords： adult     antibiotic     viral pneumonia    

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Transgenic technologies in cassava for nutritional improvement and viral disease resistance: a key strategy

Maliwan NACONSIE,Peng ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 4,   Pages 285-294 doi: 10.15302/J-FASE-2016119

Abstract: Also, two viral diseases, cassava mosaic disease (CMD) and cassava brown streak disease (CBSD), causeGenetic engineering provides promising approaches to improve nutritional value and increase resistance to viralprotein content by overexpression of nutritious storage proteins and improving cassava resistance to viral

Keywords： Manihot esculenta     protein enhancement     RNA interference     transgenesis     virus resistance    

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Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging

Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 449-461 doi: 10.1007/s11684-017-0589-5

Abstract: In this review, we summarize and discuss the latest progress in the development of small-molecule viralThese viruses can interfere with the specific steps of viral life cycle by blocking the binding betweenvirus and host cells, disrupting viral endocytosis, disturbing membrane fusion, and interrupting viralWe also discuss some general strategies for developing small-molecule viral inhibitors.

Keywords： emerging and re-emerging viruses     small-molecule inhibitor     coronavirus     Ebola virus     Zika virus     life cycle    

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Estimation of composite load model with aggregate induction motor dynamic load for an isolated hybrid

Nitin Kumar SAXENA,Ashwani Kumar SHARMA

Frontiers in Energy 2015, Volume 9, Issue 4,   Pages 472-485 doi: 10.1007/s11708-015-0373-7

Abstract: The composite load is a combination of the static and dynamic load model.To develop this composite load model, the exponential load is used as a static load model and inductionmotors (IMs) are used as a dynamic load model.This aggregate model is used as a dynamic load model.exponential model of static load and for the fifth and third order IM dynamic load model using state

Keywords： isolated hybrid power system (IHPS)     composite load model     static load     dynamic load     induction motor loadmodel     aggregate load    

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A brief review of microRNA and its role in PRRSV infection and replication

Xuekun GUO,Wenhai FENG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 114-120 doi: 10.15302/J-FASE-2014022

Abstract: shown to be capable of modulating PRRSV infection and replication by multiple ways such as targeting viralgenomic RNA, targeting viral receptor and inducing antiviral response.

Keywords： porcine reproductive and respiratory syndrome virus (PRRSV)     microRNA     antiviral     viral tropism    

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Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas

Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 497-508 doi: 10.1007/s11684-017-0572-1

Abstract:

Viral infections cause at least 10%–15% of all human carcinomas.Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamentalMeanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeutic

Keywords： genome-editing tools     tumorigenic virus     delivery method     off-target effect     virus-related carcinoma    

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Calculation method of load distribution on pipe threaded connections under tension load

Shoujun CHEN, Lianxin GAO, Qi AN

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 2,   Pages 241-248 doi: 10.1007/s11465-011-0219-x

Abstract:

This paper presents a new calculation method that can calculate the load distribution on pipe threadedconnections under tension load.the new method on the sample of P-110S pipe threaded connection, the obtained results show that the loadThe model offers a new way to calculate the loads carried on the thread teeth under tension load.

Keywords： load distribution     calculation method     pipe threaded connections     tension load    

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Comparison of optimal capacitor placement methods in radial distribution system with load growth andZIP load model

Veera Venkata Satya Naryana MURTY, Ashwani KUMAR

Frontiers in Energy 2013, Volume 7, Issue 2,   Pages 197-213 doi: 10.1007/s11708-013-0249-7

Abstract: Furthermore, the load growth factor has been considered in the study which is essential for the planningand expansion of the existing systems, whereas the impact of the realistic load model as ZIP load model

Keywords： load growth     load models     reactive power compensation     radial distribution system     power loss index (PLI)    

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Importance of Viral Disease in Dairy Cow Fertility Review

D. Claire Wathes, Chike F. Oguejiofor, Carole Thomas, Zhangrui Cheng

Engineering 2020, Volume 6, Issue 1,   Pages 26-33 doi: 10.1016/j.eng.2019.07.020

Abstract:

Many viral diseases are endemic in cattle populations worldwide.There is also significant evidence that viral infections have additional actions in dairy cows, whichAcute infection with non-cytopathic bovine viral diarrhea virus (BVDV) in mid-gestation increases abortion

Keywords： Bovine viral diarrhea virus     Bovine herpesvirus-1     Bovine herpesvirus-4     Schmallenberg virus     Bluetongue    

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A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 4,   Pages 877-894 doi: 10.1007/s11709-021-0756-2

Abstract: bridge design specifications consider multi-lane factors (MLFs) a critical component of the traffic loadapproach, the experimental site study yielded MLFs comparable with those directly calculated using traffic loadcaused the proposed approach, existing design specifications, and conventional approach of ignoring lane load

Keywords： bridges     multi-lane factor     traffic load     lane load disparity     multi-truck presence     weigh-in-motion    

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Shape design of arch dams under load uncertainties with robust optimization

Fengjie TAN, Tom LAHMER

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 4,   Pages 852-862 doi: 10.1007/s11709-019-0522-x

Abstract: The optimization of an arch-type dam is realized here by a robust optimization method under load uncertaintyThe load uncertainty is modeled as an ellipsoidal expression.

Keywords： arch dam     shape optimization     robust optimization     load uncertainty     approximation model    

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The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report

Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 333-344 doi: 10.1007/s11684-013-0275-1

Abstract:

This study reports the first death caused by a novel avian influenza A (H7N9) virus in Zhejiang Province, China. The patient had chronic hepatitis B and history of exposure to poultry. The patient initially complained of diarrhea and influenza-like symptoms on March 7 and 14 respectively. The disease progressed to severe pneumonia, sustained hypoxia, and coagulation abnormalities. The patient died on March 27 because of respiratory failure, multiple organ failure, and disseminated intravascular coagulation without oseltamivir treatment. This H7N9 virus from Zhejiang is highly similar to isolates obtained from Shanghai, Jiangsu, Anhui, etc. Analysis of hemagglutinin, neuramidinase, and matrix genes indicated that the isolates share the same avian origin, have low virulence, and are sensitive to oseltamivir, but are resistant to adamantine. Only the isolate that caused the fatality exhibited substitution of Q226I in the HA gene, which indicates a potentially enhanced human affinity. The secondary transmission rate was 1.6% (2/125). Only two health workers presented with influenza-like symptoms, and they subsequently tested negative for H7N9 RNA. In conclusion, underlying disease, late diagnosis, and untimely antiviral treatment are possible high-risk factors for infections and death caused by the low-pathogenicity avian influenza A (H7N9). Person-to-person transmission of the H7N9 virus was not detected among close contacts, but such transmission should be investigated in the future. Expanding and enhancing surveillance will help in the early discovery and diagnosis of suspected cases, which will reduce the number of severe cases and deaths.

Keywords： avian influenza A (H7N9) virus     epidemiology     contacts     person-to-person transmission    

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Title Author Date Type Operation

Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Journal Article

A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections

Journal Article

Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Journal Article

Analysis of antibiotic usage for viral community-acquired pneumonia in adults

Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li

Journal Article

Transgenic technologies in cassava for nutritional improvement and viral disease resistance: a key strategy

Maliwan NACONSIE,Peng ZHANG

Journal Article

Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging

Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang

Journal Article

Estimation of composite load model with aggregate induction motor dynamic load for an isolated hybrid

Nitin Kumar SAXENA,Ashwani Kumar SHARMA

Journal Article

A brief review of microRNA and its role in PRRSV infection and replication

Xuekun GUO,Wenhai FENG

Journal Article

Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas

Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu

Journal Article

Calculation method of load distribution on pipe threaded connections under tension load

Shoujun CHEN, Lianxin GAO, Qi AN

Journal Article

Comparison of optimal capacitor placement methods in radial distribution system with load growth andZIP load model

Veera Venkata Satya Naryana MURTY, Ashwani KUMAR

Journal Article

Importance of Viral Disease in Dairy Cow Fertility

D. Claire Wathes, Chike F. Oguejiofor, Carole Thomas, Zhangrui Cheng

Journal Article

A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

Journal Article

Shape design of arch dams under load uncertainties with robust optimization

Fengjie TAN, Tom LAHMER

Journal Article

The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report

Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia

Journal Article